Born in The Bronx, New York, Buono was raised in a blue-collar family and decided at an early age to make acting her life's ambition. At 11, she showed her connection to her family's work ethic by answering a casting call ad for Harvey Fierstein's "Spookhouse" and landing the role, without any assistance from her family or other adults. Buono began landing roles on television and the New York stage while in her teens and early twenties, and earned a Daytime Emmy nomination as a young victim of sexual abuse in Abby,